Gastrointestinal mucosal barrier function and diseases
نویسندگان
چکیده
منابع مشابه
Childhood gastrointestinal dysfunction and protection mechanism of intestinal mucosal barrier
Childhood gastrointestinal dysfunction has been recognized as the triggering elements of multiple organ failure. The causes of gastrointestinal dysfunction include: injury of intestinal barrier, release of inflammatory mediators, translocation of intestinal bacteria, gastrointestinal mucosal ischemia and anoxia injury caused by abnormal intestinal blood flow perfusion, and apoptosis of gastroin...
متن کاملTargeting Hypoxia to Augment Mucosal Barrier Function.
Sites of inflammation are associated with profound changes in tissue metabolism. Studies in vitro and in vivo have shown that the activation of the hypoxia-inducible factor (HIF) serves as an adaptive pathway for the resolution of inflammation associated with various murine disease models. The resolution of disease occurs, at least in part, through transcriptional regulation of non-classical ep...
متن کاملHelminthic therapy: improving mucosal barrier function.
The epidemiology of autoimmune diseases and helminth infections led to suggestions that helminths could improve inflammatory conditions, which was then tested using animal models. This has translated to clinical investigations aimed at the safe and controlled reintroduction of helminthic exposure to patients suffering from autoimmune diseases (so-called 'helminthic therapy') in an effort to mit...
متن کاملStress and gastrointestinal tract. II. Stress and intestinal barrier function.
The influence of stress on the clinical course of a number of intestinal diseases is increasingly being recognized, but the underlying mechanisms are largely unknown. This themes article focuses on recent findings related to the effects of stress on mucosal barrier function in the small intestine and colon. Experiments using animal models demonstrate that various types of psychological and phys...
متن کاملBiliary Mucosal Barrier and Microbiome
BACKGROUND The biliary system is in continuous contact with the complex microbiota of the intestine. Microbial products have recently been proposed as potential triggers for biliary diseases. METHODS The aim of this review is to provide a summary of the current knowledge regarding the role of the biliary and intestinal microbiome in biliary inflammatory diseases. RESULTS Previously, it was ...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology
سال: 2016
ISSN: 0944-1174,1435-5922
DOI: 10.1007/s00535-016-1207-z